When using the web client in Chrome or Firefox, NVDA does not speak the live region information when you press keys or things happen. This behavior happens with thel atest versions of NVDA, Firefox, and Chrome. Is this an NVDA issue or a problem with the web client? It works just fine with Internet Explorer 11.
There are some issues with live regions since the release of the new web client. I don't know are they NVDA issues, but currently a workaround is to go to options, choose channels and views and then set speech priority to high for all elements and it should work.